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Mouse OCD linked to Immune System

[ 0 ] July 15, 2010 | Sam McDougle

A recent study published in Cell magazine has shown that mice who exhibit “excessive grooming behavior,”  which is analogous to Obsessive-Compulsive Disorder in humans (OCD), can be cured by a bone marrow transplant.  The disorder was linked to deficient immune microglia cells, the street-cleaners of the body (they clear-up cluttery microbes and broken down cellular byproducts).  Healthy-mouse bone marrow was transferred to the OCD mice and within four months they returned to normal grooming patterns.  The gene responsible for healthy microglia – Hox8 – is a vital developmental gene, and it’s connections to observable behavioral patterns, like OCD, are intriguing and will certainly inspire further research.

Audio from the Authors:  Pathological Grooming in Mutant Mice

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  1. [...] This post was mentioned on Twitter by James Reilly and Neuro Now, Sexy Healthy Tips. Sexy Healthy Tips said: Mouse OCD linked to Immune System : The Beautiful Brain http://bit.ly/brOO4k [...]

  2. Mark Zarro says:

    This article has received a lot of attention and right so in my opinion. It really makes me wonder how many other psychological problems are actually physiological in nature.

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